FDA approves new drug to treat advanced breast cancer

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The Food and Drug Administration has approved Piqray (alpelisib) tablets to treat men and postmenopausal women whose advanced breast cancer is hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative and PIK3CA-mutated.

Piqray is to be used in combination with the FDA-approved endocrine therapy fulvestrant. The PIK3CA-mutated, advanced or metastatic breast cancer (as detected by an FDA-approved test) is indicated following progression on or after an endocrine-based regimen.

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Yes, Virginia, you should eat your broccoli

Broccoli and other cruciferous vegetables (such as arugula, Brussels sprouts, cabbage, collard greens,  cauliflower, and kale) “contain a molecule that inactivates a gene known to play a role in a variety of common human cancers” although you can’t eat your way to cancer suppression.

Scientists at Harvard Medical School’s Beth Israel Deaconess Medical Center discovered that an enzyme which plays a role in many cancers “can be inhibited with a natural compound found in broccoli and other cruciferous vegetables.” Their research is preliminary, focused on prostate cancer prone mice and human cells.

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