Metformin inhibits development of drug-resistant breast cancer

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Breast, colon, lung and hematological cancers “have high rates” of acquired resistance to chemotherapy drugs, including aromatase inhibitors for breast cancer. This phenomena, multiple drug resistance (MDR), is a major impediment to long-term cancer treatment.

That makes this research, published online December 6, 2017, groundbreaking.

[We] present the important in vitro discovery that the development of MDR (in breast cancer cells) can be prevented, and that established MDR could be resensitized to therapy, by adjunct treatment with metformin (emphasis added).

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Were these women irrational when they rejected adjuvant breast cancer treatment?

you're being emotional

Thirty percent of surveyed women with breast cancer reported skipping additional treatment following surgery. 

The implication: these women were irrational.

Although the research paper was released in November, these women were diagnosed with cancer a decade ago, 2005-2007, and the data were collected almost a decade ago, 2007-2009.

Perhaps the most egregious part of this research is that it treats “breast cancer” as a singular disease rather than the extremely heterogenous entity that it is. And how relevant are the findings to today’s patient given the age of the data?

Continue reading “Were these women irrational when they rejected adjuvant breast cancer treatment?”