What is intermittent fasting? And is it a good idea?

Fasting be back soon

Intermittent fasting, or intermittent energy restriction, is an umbrella term for a diet which involves cycling between a period of significantly reduced caloric intake (fasting) and a period of regular eating.

“Diet” or “dietary restriction” is what most of us think of as “going on a diet”, that is, reducing caloric intake.

Eating fewer calories.

Losing weight.

Those of us with estrogen-positive breast cancer who reduce our risk of recurrence by blocking the body’s estrogen production (aromatase inhibitors) … often find that weight gain is a direct side effect.

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Yes, Virginia, you should eat your broccoli

Broccoli and other cruciferous vegetables (such as arugula, Brussels sprouts, cabbage, collard greens,  cauliflower, and kale) “contain a molecule that inactivates a gene known to play a role in a variety of common human cancers” although you can’t eat your way to cancer suppression.

Scientists at Harvard Medical School’s Beth Israel Deaconess Medical Center discovered that an enzyme which plays a role in many cancers “can be inhibited with a natural compound found in broccoli and other cruciferous vegetables.” Their research is preliminary, focused on prostate cancer prone mice and human cells.

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Replumbing the lymphatic system with a pill: still a dream

microscope - pixabay

Currently no U.S. Food and Drug Administration–approved therapy can reestablish lymphatic circulation after a patient develops lymphedema. Up to 10 million people in the United States and more than 100 million around the world have lymphedema.

A phase II clinical trial at Stanford University School of Medicine tested whether the drug ubenimex, a leukemia treatment used in Japan, can spur the growth of new lymphatic vessels for patients with secondary leg lymphedema. It was the “first pharmaceutical company-sponsored trial for a medical treatment of lymphedema.”

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Metformin inhibits development of drug-resistant breast cancer

test tubes - pixabay - research

Breast, colon, lung and hematological cancers “have high rates” of acquired resistance to chemotherapy drugs, including aromatase inhibitors for breast cancer. This phenomena, multiple drug resistance (MDR), is a major impediment to long-term cancer treatment.

That makes this research, published online December 6, 2017, groundbreaking.

[We] present the important in vitro discovery that the development of MDR (in breast cancer cells) can be prevented, and that established MDR could be resensitized to therapy, by adjunct treatment with metformin (emphasis added).

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