Breast, colon, lung and hematological cancers “have high rates” of acquired resistance to chemotherapy drugs, including aromatase inhibitors for breast cancer. This phenomena, multiple drug resistance (MDR), is a major impediment to long-term cancer treatment.
That makes this research, published online December 6, 2017, groundbreaking.
[We] present the important in vitro discovery that the development of MDR (in breast cancer cells) can be prevented, and that established MDR could be resensitized to therapy, by adjunct treatment with metformin (emphasis added).
Continue reading “Metformin inhibits development of drug-resistant breast cancer”
Thirty percent of surveyed women with breast cancer reported skipping additional treatment following surgery.
The implication: these women were irrational.
Although the research paper was released in November, these women were diagnosed with cancer a decade ago, 2005-2007, and the data were collected almost a decade ago, 2007-2009.
Perhaps the most egregious part of this research is that it treats “breast cancer” as a singular disease rather than the extremely heterogenous entity that it is. And how relevant are the findings to today’s patient given the age of the data?
Continue reading “Were these women irrational when they rejected adjuvant breast cancer treatment?”
Invasive lobular cancer represents 5-15 percent of all breast cancers (depending on the study). Although it is distinctly different and responds differently to therapy, it has been treated exactly like ductal cancer for decades.
Continue reading “Crowdsourcing database of lobular breast cancer research”
A British research study followed more than 2,000 women for five years has found that targeting the tumor site, rather than the entire breast, was just as effective for women with early stage ductal breast cancer.
The results (open data) were published in The Lancet.
Continue reading “British study suggests reduced radiation effective for early stage ductal breast cancer”
The research goal was to compare of the metastatic pattern of invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) at both first distant recurrence (FDR) as well as over the entire course of metastatic disease.
Continue reading “Distinct pattern of metastases in patients with invasive lobular carcinoma of the breast”