Genomic analysis paves way for personalized treatment of invasive lobular carcinoma, UNC School of Medicine
October 8, 2015. Researchers from the UNC Lineberger Comprehensive Cancer Center and other academic centers have revealed new subtypes of invasive lobular carcinoma. The study involved the analysis of genetic and molecular patterns in more than 800 breast cancer samples, including 127 samples of invasive lobular carcinoma, a disease that’s been studied on a limited basis in previous genomic studies (emphasis added). “Lobular cancers are not a single homogeneous group, but may represent at least three different diseases that appear to differ in their microenvironmental features, and which also show differences in outcomes.” The study also reaffirmed a previous finding that loss of the function of a molecule called e-cadherin is the hallmark of invasive lobular carcinoma, and it uncovered new mutations in genes that regulate estrogen receptor signaling in these cancers.
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. Cell. 163:2, 506–519.
DOI: http://dx.doi.org/10.1016/j.cell.2015.09.033 (Open Archive).