Metformin inhibits development of drug-resistant breast cancer

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Breast, colon, lung and hematological cancers “have high rates”¬†of acquired resistance to chemotherapy drugs, including aromatase inhibitors for breast cancer. This phenomena, multiple drug resistance (MDR), is a major impediment to long-term cancer treatment.

That makes this research, published online December 6, 2017, groundbreaking.

[We] present the important in vitro discovery that the development of MDR (in breast cancer cells) can be prevented, and that established MDR could be resensitized to therapy, by adjunct treatment with metformin (emphasis added).

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